|
Symbol Name ID |
Hbb-b1
hemoglobin, beta adult major chain MGI:96021 |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormality of blood and blood-forming tissues |
Increased hematocrit |
Abnormal hemoglobin |
Reduced alpha/beta synthesis ratio |
Reduced beta/alpha synthesis ratio |
Increased HbA2 hemoglobin |
Persistence of hemoglobin F |
Increased circulating hemoglobin concentration |
Decreased mean corpuscular hemoglobin concentration |
Increased mean corpuscular volume |
Reticulocytosis |
Anemia |
Hemolytic anemia |
Chronic hemolytic anemia |
Heinz body anemia |
Nonspherocytic hemolytic anemia |
Increased red cell sickling tendency |
Hypochromic anemia |
Hypochromic microcytic anemia |
Iron deficiency anemia |
Microcytic anemia |
Erythrocyte inclusion bodies |
Heinz bodies |
Target cells |
Polycythemia |
Leukocytosis |
Venous thrombosis |
Thrombocytopenia |
Thrombocytosis |
Abnormality of the spleen |
Splenic infarction |
Splenomegaly |
| Disease(s) Associated with HBB | ||||||||||||||||||||||||||||||||
| alpha thalassemia | ||||||||||||||||||||||||||||||||
| autosomal dominant beta thalassemia | ||||||||||||||||||||||||||||||||
| beta thalassemia | ||||||||||||||||||||||||||||||||
| delta beta-thalassemia | ||||||||||||||||||||||||||||||||
| familial erythrocytosis 6 | ||||||||||||||||||||||||||||||||
| Heinz body anemia | ||||||||||||||||||||||||||||||||
| malaria | ||||||||||||||||||||||||||||||||
| sickle cell anemia |
| Mouse Phenotypes | enlarged spleen |
abnormal definitive hematopoiesis |
abnormal erythropoiesis |
extramedullary hematopoiesis |
anemia |
hemolytic anemia |
hypochromic anemia |
hypochromic microcytic anemia |
microcytic anemia |
increased erythroid progenitor cell number |
decreased erythrocyte cell number |
decreased hematocrit |
abnormal hemoglobin |
decreased hemoglobin content |
decreased mean corpuscular hemoglobin |
decreased mean corpuscular volume |
increased nucleated erythrocyte cell number |
increased red blood cell distribution width |
anisocytosis |
anisopoikilocytosis |
increased number of Heinz bodies |
leptocytosis |
poikilocytosis |
schistocytosis |
polychromatophilia |
spherocytosis |
reticulocytosis |
increased spleen iron level |
increased spleen red pulp amount |
abnormal erythrocyte physiology |
increased erythrocyte clearance |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||
| Hbb-b1MommeD7/Hbb-b1MommeD7 | ||||||||||||||||||||||||||||||||
| Hbb-b1tm1Shs/Hbb-b1tm1Shs | ||||||||||||||||||||||||||||||||
| Hbb-bh2tm1b(EUCOMM)Hmgu/Hbb-bh2tm1b(EUCOMM)Hmgu | ||||||||||||||||||||||||||||||||
| Hbb-b1MommeD7/Hbb-b1+ | ||||||||||||||||||||||||||||||||
| Hbb-b1Rbc13/Hbb-b1+ | ||||||||||||||||||||||||||||||||
| Hbb-b1tm1Shs/Hbb-b1+ | ||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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